Russia Warns Against Regime Change in Iran, Citing Global Security Risks

As tensions between Israel and Iran continue to escalate, Russia has issued a sharp warning against any attempts to impose regime change in Tehran or target Iran’s Supreme Leader, Ayatollah Ali Khamenei. In a firm statement to Sky News, Kremlin Spokesperson Dmitry Peskov declared that any assassination attempt on Khamenei would be akin to “opening Pandora’s box”, potentially unleashing a wave of radicalization and destabilization across the Middle East.

Peskov emphasized that Moscow firmly rejects any externally-driven regime change agenda in Iran, calling such efforts “unacceptable” and dangerous. He warned that assassination plots, particularly if backed by Israel and the United States, could spark uncontrollable consequences.

“If Israel, with U.S. support, orchestrates a strike on Khamenei, we would absolutely not approve. Those entertaining such ideas must understand they would awaken radical forces within Iran,” Peskov stated. “This would open Pandora’s box.”

His remarks came amid growing speculation about potential Israeli operations targeting Iranian leadership, especially after Israeli Prime Minister Benjamin Netanyahu’s ambiguous comment that such a move might “end the conflict.”

On the issue of regime change, Peskov drew a clear red line: “This is unimaginable. Even discussing this scenario is unacceptable for everyone.”

The Kremlin also warned that the ongoing Israel-Iran conflict, initiated by Israeli strikes, poses not just regional but global risks. Peskov cautioned that the clashes could draw in other international actors, creating a new cycle of violence and exacerbating instability.

Addressing another diplomatic development, Peskov downplayed U.S. President Donald Trump’s refusal to accept President Vladimir Putin’s offer of mediation, stating it wasn’t seen as an insult. “Trump has a unique way of speaking. We are tolerant — and expect the same in return,” he remarked.